{"id":3076,"date":"2026-02-02T14:14:00","date_gmt":"2026-02-02T06:14:00","guid":{"rendered":"https:\/\/www.cytopeutics.com\/?p=3076"},"modified":"2026-02-02T20:35:46","modified_gmt":"2026-02-02T12:35:46","slug":"autologous-bone-marrow-mesenchymal-stromal-cells-can-treat-arthritic-joints-of-rheumatoid-arthritis-patients-reports-of-two-patients","status":"publish","type":"post","link":"https:\/\/www.cytopeutics.com\/ms\/abstracts-publication\/autoimmune-diseases-gvhd\/autologous-bone-marrow-mesenchymal-stromal-cells-can-treat-arthritic-joints-of-rheumatoid-arthritis-patients-reports-of-two-patients\/\u00a0","title":{"rendered":"Autologous bone marrow mesenchymal stromal cells can treat arthritic joints of rheumatoid arthritis patients: Reports of two patients."},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3076\" class=\"elementor elementor-3076\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70ccd87 e-flex e-con-boxed e-con e-parent\" data-id=\"70ccd87\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f9ff919 elementor-widget elementor-widget-heading\" data-id=\"f9ff919\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Affiliation<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98f281e elementor-widget elementor-widget-text-editor\" data-id=\"98f281e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cytopeutics, Selangor, Malaysia<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mawar Hospital, Negeri Sembilan, Malaysia<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Beverly Wilshire Medical Centre, Kuala Lumpur, Malaysia<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">International Medical University, Negeri Sembilan, Malaysia<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cryocord, Selangor, Malaysia<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tunku Abdul Rahman University, Selangor, Malaysia<\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e64448c elementor-widget elementor-widget-heading\" data-id=\"e64448c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Background<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-506a260 elementor-widget elementor-widget-text-editor\" data-id=\"506a260\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Adult human bone marrow (BM) contains a population of mesenchymal stromal cells (MSC) that contribute to tissue regeneration. Further interest in the clinical application of MSC has been generated by the observation that MSC can exert profound immunosuppression by inhibiting T-cell activities in vitro. Rheumatoid arthritis (RA) is a T-cell-mediated systemic autoimmune disease characterized by cartilage and bone destruction associated with local production of inflammatory mediators. Joint destruction renders RA a candidate disease for cartilage repair using MSC. However, the issue of whether MSC from patients with RA are functionally altered must be addressed before proceeding to clinical application. The aim of this study was to investigate the properties of BMMSC isolated from patients with active RA in vitro and the efficacy of treating arthritic joints of RA patients with autologous BMMSC by intra-articular injection.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5e504e elementor-widget elementor-widget-heading\" data-id=\"d5e504e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Methods<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1f7185 elementor-widget elementor-widget-text-editor\" data-id=\"b1f7185\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Two patients were recruited. BMMSC were isolated and characterized (including tri-differentiation immunosuppression assay) before implanting the cells back into patients.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e6ee82 elementor-widget elementor-widget-heading\" data-id=\"2e6ee82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Results<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7544041 elementor-widget elementor-widget-text-editor\" data-id=\"7544041\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">BMMSC were successfully isolated from patients. These BMMSC can differentiate into adipocytes, osteocytes and chondrocytes. Isolated MSC also showed immunosuppressive ability when co-cultured with activated autologous peripheral blood T-cells. Subsequently, successfully isolated and characterized MSC were injected back into patient A&#8217;s knee joints and patient B&#8217;s hips. At 1 month after autologous BMMSC implantation, significant reduction of rheumatoid factor was observed in both patients.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dca7fc elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6dca7fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-834f61f elementor-widget elementor-widget-heading\" data-id=\"834f61f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclusions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33b90fb elementor-widget elementor-widget-text-editor\" data-id=\"33b90fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">This preliminary study showed the properties of BMMSC from RA patients were comparable to healthy MSC, and can be used for autologous transplantation.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Affiliation Cytopeutics, Selangor, Malaysia Mawar Hospital, Negeri Sembilan, Malaysia Beverly Wilshire Medical Centre, Kuala Lumpur, Malaysia International Medical University, Negeri Sembilan, Malaysia Cryocord, Selangor, Malaysia Tunku Abdul Rahman University, Selangor, Malaysia Background Adult human bone marrow (BM) contains a population of mesenchymal stromal cells (MSC) that contribute to tissue regeneration. Further interest in the clinical [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3077,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[41],"tags":[],"class_list":["post-3076","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-autoimmune-diseases-gvhd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Autologous bone marrow mesenchymal stromal cells can treat arthritic joints of rheumatoid arthritis patients: Reports of two patients. - Cytopeutics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cytopeutics.com\/abstracts-publication\/autoimmune-diseases-gvhd\/autologous-bone-marrow-mesenchymal-stromal-cells-can-treat-arthritic-joints-of-rheumatoid-arthritis-patients-reports-of-two-patients\/\u00a0\" \/>\n<meta property=\"og:locale\" content=\"ms_MY\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Autologous bone marrow mesenchymal stromal cells can treat arthritic joints of rheumatoid arthritis patients: Reports of two patients. - Cytopeutics\" \/>\n<meta property=\"og:description\" content=\"Affiliation Cytopeutics, Selangor, Malaysia Mawar Hospital, Negeri Sembilan, Malaysia Beverly Wilshire Medical Centre, Kuala Lumpur, Malaysia International Medical University, Negeri Sembilan, Malaysia Cryocord, Selangor, Malaysia Tunku Abdul Rahman University, Selangor, Malaysia Background Adult human bone marrow (BM) contains a population of mesenchymal stromal cells (MSC) that contribute to tissue regeneration. 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