{"id":3033,"date":"2026-02-02T14:20:00","date_gmt":"2026-02-02T06:20:00","guid":{"rendered":"https:\/\/www.cytopeutics.com\/?p=3033"},"modified":"2026-02-03T14:55:05","modified_gmt":"2026-02-03T06:55:05","slug":"bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study","status":"publish","type":"post","link":"https:\/\/www.cytopeutics.com\/ms\/abstracts-publication\/stroke-brain-spinal-cord-injuries\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\/\u00a0","title":{"rendered":"BM-MCS Accelerates Acute Stroke Recovery In A Randomized Placebo-controlled Clinical Phase Ii\/iii Study"},"content":{"rendered":"\t\t
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Background<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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We previously demonstrated that mesenchymal stromal cell (MSC) may be transdifferentiated into neuron-like cells. MSC may also help attenuate cerebral oedema and hasten recovery following acute stroke. Furthermore, the blood-brain barrier is semipermeable in the acute stroke period which allows MSC to be administered intravenously. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Seventeen patients with acute middle cerebral artery stroke were recruited and randomized to receive best medical care plus autologous bone marrow-derived MSC (Group A-MSC; n = 9) or best medical care alone (Group B- Placebo; n = 8). There were no significant differences in age or comorbidities. Group A patients received 100\u2013200×106 MSC intravenously at 1 month after acute stroke. The internationally-validated scales of Barthel index (BI), National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Score (mRS) were used to record the disability and functional progress at baseline (stroke onset), 6 weeks, 3 months, 6 months and 12 months follow up.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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All patients were severely disabled following acute stroke (Baseline [Mean \u00b1 1SD] for mRS [4 \u00b1 1]; BI [14 \u00b1 17] and NIHSS [17 \u00b1 6], no difference between both arms. One patient died in each group due to sudden death (Group A) and septicaemia secondary to pressure sores (Group B). Both groups showed improvement in NIHSS, BI and mRS over time but the improvement was only significant in Group A. Intergroup comparison revealed that mean BI was higher for Group A at 6-weeks follow-up when compared to Group B (70 \u00b1 31 vs 26 \u00b1 38, P = 0.041). There were continuing improvement in BI in Group A at 6 and 12 months compared with Group B but not significant [6 months (85 \u00b1 11 vs. 55 \u00b1 46, P = NS) and 12 months (91 \u00b1 8 vs. 67 \u00b1 58, P = NS)].\u00a0\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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MSC administered intravenously in the sub-acute period following severe stroke is safe and efficacious, and results in accelerated recovery in the initial period. More studies are warranted.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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  1. Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia<\/span><\/li>
  2. Cytopeutics, Selangor, Malaysia<\/span><\/li>
  3. Cell Therapy Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia<\/span><\/li>
  4. Tunku Abdul Rahman University, Selangor, Malaysia<\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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    \n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tDownload paper<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Background We previously demonstrated that mesenchymal stromal cell (MSC) may be transdifferentiated into neuron-like cells. MSC may also help attenuate cerebral oedema and hasten recovery following acute stroke. Furthermore, the blood-brain barrier is semipermeable in the acute stroke period which allows MSC to be administered intravenously. Methods Seventeen patients with acute middle cerebral artery stroke […]<\/p>\n","protected":false},"author":1,"featured_media":3034,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-3033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-stroke-brain-spinal-cord-injuries"],"acf":[],"yoast_head":"\nBM-MCS Accelerates Acute Stroke Recovery In A Randomized Placebo-controlled Clinical Phase Ii\/iii Study - Cytopeutics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cytopeutics.com\/abstracts-publication\/stroke-brain-spinal-cord-injuries\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\/\u00a0\" \/>\n<meta property=\"og:locale\" content=\"ms_MY\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BM-MCS Accelerates Acute Stroke Recovery In A Randomized Placebo-controlled Clinical Phase Ii\/iii Study - Cytopeutics\" \/>\n<meta property=\"og:description\" content=\"Background We previously demonstrated that mesenchymal stromal cell (MSC) may be transdifferentiated into neuron-like cells. MSC may also help attenuate cerebral oedema and hasten recovery following acute stroke. Furthermore, the blood-brain barrier is semipermeable in the acute stroke period which allows MSC to be administered intravenously. Methods Seventeen patients with acute middle cerebral artery stroke […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cytopeutics.com\/abstracts-publication\/stroke-brain-spinal-cord-injuries\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\/\u00a0\" \/>\n<meta property=\"og:site_name\" content=\"Cytopeutics\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-02T06:20:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-03T06:55:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cytopeutics.com\/wp-content\/uploads\/2026\/01\/Paper7-Stroke-2016.png.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1654\" \/>\n\t<meta property=\"og:image:height\" content=\"2339\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minit\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.cytopeutics.com\\\/abstracts-publication\\\/stroke-brain-spinal-cord-injuries\\\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\\\/\u00a0#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cytopeutics.com\\\/abstracts-publication\\\/stroke-brain-spinal-cord-injuries\\\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\\\/\u00a0\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/www.cytopeutics.com\\\/#\\\/schema\\\/person\\\/72f689cc496b83192f8c287d93a8915f\"},\"headline\":\"BM-MCS Accelerates Acute Stroke Recovery In A Randomized Placebo-controlled Clinical Phase Ii\\\/iii Study\",\"datePublished\":\"2026-02-02T06:20:00+00:00\",\"dateModified\":\"2026-02-03T06:55:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.cytopeutics.com\\\/abstracts-publication\\\/stroke-brain-spinal-cord-injuries\\\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\\\/\u00a0\"},\"wordCount\":334,\"publisher\":{\"@id\":\"https:\\\/\\\/www.cytopeutics.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.cytopeutics.com\\\/abstracts-publication\\\/stroke-brain-spinal-cord-injuries\\\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\\\/\u00a0#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.cytopeutics.com\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/Paper7-Stroke-2016.png.webp\",\"articleSection\":[\"Stroke, Brain & Spinal Cord Injuries\"],\"inLanguage\":\"ms-MY\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cytopeutics.com\\\/abstracts-publication\\\/stroke-brain-spinal-cord-injuries\\\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\\\/\u00a0\",\"url\":\"https:\\\/\\\/www.cytopeutics.com\\\/abstracts-publication\\\/stroke-brain-spinal-cord-injuries\\\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\\\/\u00a0\",\"name\":\"BM-MCS Accelerates Acute Stroke Recovery In A Randomized Placebo-controlled Clinical Phase Ii\\\/iii Study - 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Methods Seventeen patients with acute middle cerebral artery stroke […]","og_url":"https:\/\/www.cytopeutics.com\/abstracts-publication\/stroke-brain-spinal-cord-injuries\/bm-msc-accelerates-acute-stroke-recovery-in-a-randomized-placebo-controlled-clinical-phase-ii-iii-study\/\u00a0","og_site_name":"Cytopeutics","article_published_time":"2026-02-02T06:20:00+00:00","article_modified_time":"2026-02-03T06:55:05+00:00","og_image":[{"width":1654,"height":2339,"url":"https:\/\/www.cytopeutics.com\/wp-content\/uploads\/2026\/01\/Paper7-Stroke-2016.png.webp","type":"image\/webp"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"2 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