Immunomodulation

Dose-dependent Immunomodulatory Effect of Intravenous Allogeneic Umbilical Cord-Derived Mesenchymal Stromal Cells (Cytopeutics CLV-100) Infusion in Healthy Volunteers

SP Chin1, KY Then2, SK Cheong3

1NSCMH Medical Centre, Seremban, Negeri Sembilan, Malaysia, 2Universiti Tunku Abdul Rahman, Bandar Sungai Long, Selangor,  Malaysia, 3Cytopeutics, Cyberjaya,

mean of IL-RA (anti-inflammatory factor)

Figure 1. IL1-RA level of all subjects in LD and HD group. The anti-inflammatory IL-1RA was significantly elevated in HD subjects from Day 2 compared to baseline (436+128 s,615+148 pg/mL; p=0.028). *Significant value at p<0.05 with The Wilcoxon Signed-Rank Test.

mean of anti-inflammatory factor

Figure 2. Concentration of biomarkers with different time point. *Significant value at p<0.05 between LD and HD group by using The Mann-Whitney Test.